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It came out of a structure-guided screen of N-methylated quinolinium, isoquinolinium, pyridinium and benzimidazolium analogues reported by Neelakantan and colleagues in the Journal of Medicinal Chemistry in 2017, where the quinolinium scaffold emerged as the most tractable and 5-amino substitution gave an IC50 near 1 µM against the human enzyme

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Palmitoyl pentapeptide-4, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-7 are the ones you will meet on an ingredient list